Findings

What do systematic reviews say?

398 questions · 434 findings · 166 reviews

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No studies found 95 · 21.9%GRADE not reported 31 · 7.1%Very low 91 · 21%Low 110 · 25.3%Moderate 78 · 18%High 29 · 6.7%

Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate

All‐cause mortality · people with CKD‐MBD

The review found no eligible studies for this question.

1 finding from 1 review

Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low phosphorus intake (avoiding food additives) vs normal diet

All‐cause mortality · people with CKD‐MBD

Low phosphorus intake (avoiding food additives) showed no clear difference in mortality compared with normal diet (moderate certainty).

1 finding from 1 review

Dietary interventions for mineral and bone disorder in people with chronic kidney disease 2015 · Cochrane Headline outcomes only
RR 0.18 [0.01, 3.82]
1 study · 279 participants
Moderate

Supervised exercise therapy following vascular intervention vs vascular intervention alone

All‐cause mortality · people with symptomatic peripheral arterial disease§

It is very uncertain whether supervised exercise therapy following vascular intervention changes mortality compared with vascular intervention alone (very low certainty).

1 finding from 1 review

Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral… 2024 · Cochrane Headline outcomes only
OR 0.92 [0.42, 2]
6 studies · 346 participants
Very low

Low glycaemic index (GI) or glycaemic load (GL) diets vs higher GI or GL diets

All‐cause mortality · Adults or children with overweight or obesity

The review found no eligible studies for this question.

1 finding from 1 review

Low glycaemic index or low glycaemic load diets for people with overweight or obesity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low glycaemic index (GI) or glycaemic load (GL) diets vs any other diet

All‐cause mortality · Adults or children with overweight or obesity

The review found no eligible studies for this question.

1 finding from 1 review

Low glycaemic index or low glycaemic load diets for people with overweight or obesity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
RR 0.67 [0.24, 1.85]
1 study · 893 participants
Moderate

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
RR 0.88 [0.29, 2.65]
3 studies · 2036 participants
Low

TACE followed by 3‐DCRT vs chemoembolisation

All‐cause mortality: at 3 years · primary hepatocellular carcinoma

TACE followed by 3‐DCRT may leads to lower all‐cause mortality: at 3 years compared with TACE (low certainty).

1 finding from 1 review

Transcatheter arterial chemoembolisation followed by three‐dimensional conformal radiotherapy versus transcatheter… 2019 · Cochrane Headline outcomes only
RR 0.8 [0.73, 0.88]
7 studies · 552 participants
Low

Lower blood pressure targets vs standard blood pressure targets

Total mortality · adult patients with hypertension

Lower BP target showed no clear difference in total mortality compared with standard BP target (high certainty).

1 finding from 1 review

Blood pressure targets in adults with hypertension 2020 · Cochrane Headline outcomes only
RR 0.95 [0.86, 1.05]
Studies not reported
High

Unfractionated heparin vs low molecular weight heparin

All cause mortality · people undergoing major amputation of the lower extremity

The review found no eligible studies for this question.

1 finding from 1 review

Primary prophylaxis for venous thromboembolism in people undergoing major amputation of the lower extremity 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Protocol to increase global blood flow vs control

Mortality (Hospital or 28‐day) · surgical patients

Protocol to increase global blood flow showed no clear difference in mortality (Hospital or 28‐day) compared with control (low certainty).

1 finding from 1 review

Perioperative increase in global blood flow to explicit defined goals and outcomes following surgery 2012 · Cochrane Headline outcomes only
RR 0.81 [0.65, 1]
31 studies · 5292 participants
Low

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low molecular weight heparin vs control

Death during study period · children with a CVC

1 finding from 1 review

Low molecular weight heparin for prevention of central venous catheter‐related thrombosis in children 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 813 participants
Low

Low‐dose computed tomography (LDCT) screening vs no LDCT screening

All‐cause mortality ‐ planned time points · healthy adults

Low‐dose computed tomography (LDCT) screening probably leads to lower all‐cause mortality ‐ planned time points compared with no LDCT screening (moderate certainty).

1 finding from 1 review

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality 2022 · Cochrane Headline outcomes only
RR 0.95 [0.91, 0.99]
8 studies · 91107 participants
Moderate

Direct thrombin inhibitors vs low molecular weight heparin

All‐cause Mortality events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors probably leads to higher all‐cause Mortality events compared with low molecular weight heparins (moderate certainty).

1 finding from 1 review

Direct thrombin inhibitors versus vitamin K antagonists or low molecular weight heparins for prevention of venous… 2010 · Cochrane Headline outcomes only
OR 2.06 [1.1, 3.87]
11 studies · 22065 participants
Moderate

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Low‐carbohydrate weight‐reducing diets vs balanced‐carbohydrate weight‐reducing diets

Cardiovascular mortality ‐ not measured · overweight and obese participants with T2DM (weight‐reducing phase only)

The review found no eligible studies for this question.

1 finding from 1 review

Low‐carbohydrate versus balanced‐carbohydrate diets for reducing weight and cardiovascular risk 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found