Cochrane · systematic review · CD010350
Dietary interventions for mineral and bone disorder in people with chronic kidney disease
Liu, Z, Su, G, Guo, X, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Kidney and TransplantAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
40
current version
GRADE rated
20
No studies
20
Included studies
NR
No studies 20 · 50%Ungraded 0 · 0%Very low 19 · 47.5%Low 0 · 0%Moderate 1 · 2.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Calcium‐enriched bread versus calcium acetate for people with CKD‐MBD
Population: people with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Calcium‐enriched bread vs calcium acetate | no estimate extracted | 1 study · 53 participants | Very low Downgraded: risk of bias |
Serum calcium Calcium‐enriched bread vs calcium acetate | no estimate extracted | 1 study · 53 participants | Very low Downgraded: risk of bias |
Calcium × phosphate product Calcium‐enriched bread vs calcium acetate | no estimate extracted | 1 study · 53 participants | Very low Downgraded: risk of bias |
Alkaline phosphatase activity Calcium‐enriched bread vs calcium acetate | no estimate extracted | 1 study · 53 participants | Very low Downgraded: risk of bias |
Mortality Calcium‐enriched bread vs calcium acetate | no estimate extracted | NR | No studies |
Cardiovascular events Calcium‐enriched bread vs calcium acetate | no estimate extracted | NR | No studies |
Fracture Calcium‐enriched bread vs calcium acetate | no estimate extracted | NR | No studies |
Very low versus low protein diet for people with CKD‐MBD
Population: people with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Very low vs low protein diet | no estimate extracted | 2 studies · 41 participants | Very low Downgraded: risk of bias, imprecision |
PTH Very low vs low protein diet | no estimate extracted | 2 studies · 41 participants | Very low Downgraded: risk of bias, imprecision |
Serum calcium Very low vs low protein diet | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias |
Alkaline phosphatase Very low vs low protein diet | no estimate extracted | 1 study · 22 participants | Very low Downgraded: risk of bias |
Mortality Very low vs low protein diet | no estimate extracted | NR | No studies |
Cardiovascular events Very low vs low protein diet | no estimate extracted | NR | No studies |
Fracture Very low vs low protein diet | no estimate extracted | NR | No studies |
Low phosphorus versus normal diet for people with CKD‐MBD
Population: people with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Low phosphorus vs normal diet | no estimate extracted | 1 study · 80 participants | Very low Downgraded: risk of bias |
Mortality Low phosphorus vs normal diet | no estimate extracted | NR | No studies |
Cardiovascular events Low phosphorus vs normal diet | no estimate extracted | NR | No studies |
Fracture Low phosphorus vs normal diet | no estimate extracted | NR | No studies |
Post‐haemodialysis dietary supplement versus normal diet for people with CKD‐MBD
Population: people with CKD‐MBD undergoing haemodialysis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision |
Serum phosphorus ‐ home‐prepared dietary supplement versus normal diet Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | 1 study · 30 participants | Very low Downgraded: risk of bias |
Serum phosphorus ‐ commercial dietary supplement versus normal diet Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | 1 study · 24 participants | Very low Downgraded: risk of bias |
Mortality Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | NR | No studies |
Cardiovascular events Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | NR | No studies |
Fracture Post‐haemodialysis dietary supplement vs normal diet | no estimate extracted | NR | No studies |
Low phosphorus intake (avoiding food additives) versus normal diet for people with CKD‐MBD
Population: patients with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Low phosphorus intake (avoiding food additives) vs normal diet | no estimate extracted | 1 study · 279 participants | Very low Downgraded: risk of bias |
Mortality Low phosphorus intake (avoiding food additives) vs normal diet | RR 0.18 [0.01, 3.82] | 1 study · 279 participants | Moderate |
Cardiovascular events Low phosphorus intake (avoiding food additives) vs normal diet | no estimate extracted | NR | No studies |
Fracture Low phosphorus intake (avoiding food additives) vs normal diet | no estimate extracted | NR | No studies |
Low phosphorus intake plus placebo versus ad libitum diet plus placebo for people with CKD‐MBD
Population: patients with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | 1 study · 20 participants | Very low |
FGF‐23 Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | 1 study · 20 participants | Very low Downgraded: risk of bias |
PTH Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | 1 study · 20 participants | Very low Downgraded: risk of bias |
Mortality Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | NR | No studies |
Cardiovascular events Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | NR | No studies |
Fracture Low phosphorus intake plus placebo vs ad libitum diet plus placebo | no estimate extracted | NR | No studies |
Low phosphorus intake plus lanthanum carbonate versus ad libitum diet plus lanthanum carbonate for people with CKD‐MBD
Population: patients with CKD‐MBD
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serum phosphorus Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | 1 study · 19 participants | Very low Downgraded: risk of bias |
FGF‐23 Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | 1 study · 19 participants | Very low Downgraded: risk of bias |
PTH Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | 1 study · 19 participants | Very low Downgraded: risk of bias |
Mortality Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | NR | No studies |
Cardiovascular events Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | NR | No studies |
Fracture Low phosphorus intake plus lanthanum carbonate vs ad libitum diet plus lanthanum carbonate | no estimate extracted | NR | No studies |