Cochrane · systematic review · CD013829
Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality
Bonney, A, Malouf, R, Marchal, C, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Lung CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
6
No studies
1
Included studies
NR
No studies 1 · 14.3%Ungraded 0 · 0%Very low 0 · 0%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Low‐dose computed tomography (LDCT) screening compared to no LDCT screening for lung cancer‐related mortality
Population: healthy adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Lung cancer‐related mortality ‐ planned time points Low‐dose computed tomography (LDCT) screening vs no LDCT screening | RR 0.79 [0.72, 0.87] | 8 studies · 91122 participants | Moderate Downgraded: risk of bias |
All‐cause mortality ‐ planned time points Low‐dose computed tomography (LDCT) screening vs no LDCT screening | RR 0.95 [0.91, 0.99] | 8 studies · 91107 participants | Moderate Downgraded: risk of bias |
Overdiagnosis Time point: ≥ 10 years from randomisation excluding CXR trials  Low‐dose computed tomography (LDCT) screening vs no LDCT screening | RD 0.18 | 5 studies · 28656 participants | Low Downgraded: risk of bias, inconsistency |
Number of invasive tests Time point: 3 years to 10 years from randomisation  Low‐dose computed tomography (LDCT) screening vs no LDCT screening | 2.6 [2.41, 2.8] | 3 studies · 60003 participants | Moderate Downgraded: risk of bias |
Any death postsurgery Time point: 6 years to 9 years from randomisation Low‐dose computed tomography (LDCT) screening vs no LDCT screening | RR 0.68 [0.24, 1.94] | 2 studies · 409 participants | Moderate Downgraded: risk of bias |
Health‐related quality of life ‐ anxiety Time point: 10 months to 5 years from randomisation Measured by different scales Low‐dose computed tomography (LDCT) screening vs no LDCT screening | no estimate extracted | 3 studies · 8153 participants | Low Downgraded: risk of bias, indirectness |
 Low‐dose computed tomography (LDCT) screening vs no LDCT screening | no estimate extracted | NR | No studies |