Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

398 questions · 434 findings · 166 reviews

No studies found 95 · 21.9%GRADE not reported 31 · 7.1%Very low 91 · 21%Low 110 · 25.3%Moderate 78 · 18%High 29 · 6.7%

Direct oral anticoagulant secondary prophylaxis vs Low molecular weight heparin secondary prophylaxis

All‐cause mortality · patients with cancer with venous thromboembolism

Direct oral anticoagulant secondary prophylaxis showed no clear difference in all‐cause mortality compared with low molecular weight heparin secondary prophylaxis (low certainty).

1 finding from 1 review

Intervention not reported

Perinatal mortality · women in late pregnancy (after 24 weeks' gestation) in both unselected populations and designated low‐risk populations

The intervention showed no clear difference in perinatal mortality (moderate certainty).

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

All cause mortality · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality, Patients with chronic kidney disease: RR 0.86 (95% CI 0.81 to 0.92), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

All cause mortality · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for All cause mortality: HR 0.72 (95% CI 0.66 to 0.78), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Targeted individualized vs standard non‐individualized fortification

In‐hospital mortality · promoting growth and development in very low birth weight infants receiving human milk

It is very uncertain whether targeted individualized changes in‐hospital mortality compared with standard non‐individualized fortification (very low certainty).

1 finding from 1 review

Exercise vs no exercise at longest available follow‐up

All‐cause mortality ( · adult patients with an implantable cardioverter defibrillator

It is very uncertain whether exercise changes all‐cause mortality ( compared with no exercise at longest available follow‐up (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs SDAC + hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (carbamazepine, yellow oleander, or combinations of different drugs)

It is very uncertain whether MDAC + hospital intervention changes incidence of mortality compared with SDAC + hospital intervention (very low certainty).

1 finding from 1 review

MDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (benzodiazepines, yellow oleander or combinations of different drugs)

MDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention (low certainty).

1 finding from 1 review

SDAC + hospital intervention vs hospital intervention

Incidence of mortality · first aid in patients with acute oral poisoning (not specified, tricyclic antidepressants, combinations of different drugs or yellow…

SDAC + hospital intervention showed no clear difference in incidence of mortality compared with hospital intervention alone (low certainty).

1 finding from 1 review

Higher threshold (500 mL per six hours or greater) vs lower threshold (less than 500 mL per six hours) at time of aspiration

Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube

It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade (condom‐loaded catheter) vs uterovaginal packing (intrauterine tamponade versus another intrauterine tamponade method)

Mortality due to bleeding · Women (aged between 20 and 40) diagnosed with primary PPH following 'normal' vaginal birth and unresponsive to medical treatment (Ashraf…

The review found no eligible studies for this question.

1 finding from 1 review

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Mortality due to bleeding · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review