Findings

What do systematic reviews say?

7 questions · 7 findings · 7 reviews · Gynaecology and Fertility

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 1 · 14.3%Moderate 3 · 42.9%High 1 · 14.3%

Embryo culture with low oxygen concentration vs embryo culture with atmospheric oxygen concentration

Live birth rate · Patients with live birth rate

Embryo culture with low oxygen concentration probably leads to higher live birth rate compared with embryo culture with atmospheric oxygen concentration (moderate certainty).

1 finding from 1 review

Low oxygen concentrations for embryo culture in assisted reproductive technologies 2012 · Cochrane Headline outcomes only
OR 1.39 [1.11, 1.76]
3 studies · 1291 participants
Moderate

Low‐frequency electroacupuncture vs physical exercise or no intervention

Live birth rate · polycystic ovarian syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture for polycystic ovarian syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High vs low or no hyaluronic acid

Live birth rate · couples undergoing embryo transfer

High probably leads to higher live birth rate ‐ high vs low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 1.21 [1.11, 1.31]
10 studies · 4066 participants
Moderate

Long‐acting FSH (all doses) vs daily FSH

Live birth rate

Long‐acting FSH (all doses) probably leads to lower live birth rate ‐ Low dose (60 to 120 μg) compared with daily FSH (moderate certainty).

1 finding from 1 review

Long‐acting FSH versus daily FSH for women undergoing assisted reproduction 2015 · Cochrane Headline outcomes only
RR 0.7 [0.52, 0.93]
3 studies · 645 participants
Moderate

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Live birth rate per woman · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes live birth rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection 2016 · Cochrane Headline outcomes only
RR 1.05 [0.89, 1.23]
3 studies · 1200 participants
Very low

Letrozole with or without adjuncts vs SERMs with or without adjuncts followed by timed intercourse

Live birth rate · infertile women with polycystic ovary syndrome

Letrozole with or without adjuncts leads to higher live birth rate compared with SERMs with or without adjuncts followed by timed intercourse (high certainty).

1 finding from 1 review

Aromatase inhibitors (letrozole) for ovulation induction in infertile women with polycystic ovary syndrome 2022 · Cochrane Headline outcomes only
OR 1.72 [1.4, 2.11]
11 studies · 2060 participants
High

Metformin vs placebo co‐treatment

Live birth rate per woman · subfertile women with polycystic ovary syndrome

Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.31 [1.24, 4.33]
2 studies · 180 participants
Low