Cochrane · systematic review · CD009090
Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome
Bordewijk, EM, Nahuis, M, Costello, MF, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Metformin versus placebo co‐treatment for assisted reproduction for subfertility associated with polycystic ovary syndrome
Population: patients with subfertility associated with polycystic ovary syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth rate (per woman) Metformin vs placebo co‐treatment | OR 2.31 [1.24, 4.33] | 2 studies · 180 participants | Low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate (per woman) Metformin vs placebo co‐treatment | OR 0.55 [0.15, 1.95] | 4 studies · 232 participants | Low Downgraded: risk of bias, imprecision |
Ongoing pregnancy rate (per woman) Metformin vs placebo co‐treatment | OR 2.46 [1.36, 4.46] | 4 studies · 232 participants | Low Downgraded: risk of bias, imprecision |
Clinical pregnancy rate (per woman) Metformin vs placebo co‐treatment | OR 2.51 [1.46, 4.31] | 5 studies · 264 participants | Low Downgraded: risk of bias, imprecision |