Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

194 questions · 205 findings · 74 reviews · Headline outcomes only

No studies found 49 · 23.9%GRADE not reported 19 · 9.3%Very low 63 · 30.7%Low 48 · 23.4%Moderate 25 · 12.2%High 1 · 0.5%

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

2 findings from 1 review

Community professional‐led interventions vs no care

Depression symptoms (1 to 6 months post intervention) Beck Depression Inventorye; Oxford Measure of Psychosocial Adjustmentd (higher score = higher severity) · children/adolescents with post‐traumatic stress and related depressive/anxiety symptoms
1 finding from 1 review

Evidence‐based psychological interventions vs any comparator

Evidence‐based psychological interventions versus any comparator (Universal programmes) ‐ self‐rated depression scores (higher score is equivalent to a poorer outcome) · Children or adolescents
1 finding from 1 review

Antidepressants vs placebo

Depression: meeting study criteria for depression at end of · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes depression: meeting study criteria for depression at end treatment… compared with placebo (very low certainty).

1 finding from 1 review

Evidence‐based psychological interventions vs any comparator

Diagnosis of depression · Children or adolescents

Evidence‐based psychological interventions probably leads to lower evidence‐based psychological interventions versus any comparator… compared with any comparator (moderate certainty).

3 findings from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review