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Evidence found and GRADE certainty

417 questions · 819 findings · 72 reviews · Oral Health

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No studies found 9 · 1.1%GRADE not reported 759 · 92.7%Very low 39 · 4.8%Low 5 · 0.6%Moderate 6 · 0.7%High 1 · 0.1%

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

The evidence is very uncertain about the effect of overweight/obesity on caries odds in the permanent dentition (very low certainty).

1 finding from 1 review

Slum residence vs Non-slum urban setting

Dental caries · Adult residents of slums and non-slum urban settings of LMICs

Slum residents had non-significantly higher odds of caries than non-slum residents (OR 1.21, 95% CI 0.94-1.56; single study); ungraded.

1 finding from 1 review

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by WHO 2006 Z-score)

A meta-analysis of 2 studies (permanent dentition, WHO 2006 Z-score) was rated very low certainty; the pooled effect was not shown in the article.

1 finding from 1 review

Obesity (Unclassified) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)

Normal-weight adolescents in the permanent dentition probably have greater odds of dental caries than obese peers (OR 2.53; moderate certainty).

1 finding from 1 review

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children under 5 years in primary dentition (BMI classified by WHO 2006 Z-score)

The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (WHO 2006 Z-score; very low certainty).

1 finding from 1 review

Obesity (Unclassified) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)

The evidence is very uncertain about the effect of obesity on caries odds in the primary dentition (very low certainty).

1 finding from 1 review

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children/adolescents (BMI classified by WHO 2007 percentile)

The evidence is very uncertain about the effect of overweight/obesity on caries odds (WHO 2007 percentile; very low certainty).

1 finding from 1 review

Overweight/obesity (combined) vs Normal Weight or Non‐Obese

Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)

The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (very low certainty).

1 finding from 1 review

Non-syndromic cleft lip and palate (CLP) status and its oral microbiota (exposure/grouping) vs Children and adolescents aged 0-18 years without CLP (controls)

Dental caries · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)

Pooling 3 studies, children/adolescents with CLP were about 2.03 times more likely to have dental caries than non-CLP controls (p<0.005; low heterogeneity), though most included studies were at high risk of bias; the evidence is ungraded.

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Dental caries prevalence · Children or adolescents

In permanent dentition, CLWH on ART had higher caries prevalence than healthy controls (OR 2.49, 95% CI 1.86 to 3.32; single study).

3 findings from 1 review

Simple childhood caries prediction models with at least two predictors vs No competing model

Dental caries discrimination (area under the curve) · Children or adolescents

The Luo (2021) model had an AUC of 0.77 (95% CI 0.76 to 0.77).

6 findings from 1 review
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Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Dental caries (by severity) · Children or adolescents

One study reported higher median caries severity among CLWH under 12 years; no meta-analytic estimate was pooled.

1 finding from 1 review

TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CT/CC genotype vs TT genotype (dominant model)

Dental caries susceptibility · Children and adults (no age limit) assessed for dental caries susceptibility

No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries for mixed dentition caries under the dominant (CT/CC vs TT) model (OR 1.37, 95% CI 0.81 to 2.33); ungraded.

6 findings from 1 review
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TaqI (rs731236 T>C) polymorphism in the VDR gene (C allele / variant genotype) vs CC genotype vs TT genotype (homozygous model)

Dental caries susceptibility · Children and adults (no age limit) assessed for dental caries susceptibility

No significant association between the TaqI (rs731236 T>C) polymorphism and dental caries in Asians under the homozygous (CC vs TT) model (OR 1.38, 95% CI 0.55 to 3.50); ungraded.

6 findings from 1 review
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