Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 13 findings · 6 reviews · Headline outcomes only

No studies found 2 · 15.4%GRADE not reported 0 · 0%Very low 4 · 30.8%Low 2 · 15.4%Moderate 2 · 15.4%High 3 · 23.1%

Early ART vs standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl)

Death · patients with asymptomatic, HIV‐infected, treatment naive adults

Early ART probably leads to lower death compared with standard or deferred ART (CD4 <= 200 or CD4 <= 250 cells/µl) (moderate certainty).

1 finding from 1 review

Very early cerebral revascularization vs delayed treatment

Perioperative death and strokes · people with recently symptomatic carotid artery stenosis

It is very uncertain whether very early cerebral revascularization changes stroke and Death < 30 days compared with delayed treatment (very low certainty).

2 findings from 1 review

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Chemotherapy alone vs same chemotherapy plus radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early and advanced stages)

Chemotherapy alone showed no clear difference in death compared with same chemotherapy plus radiotherapy (moderate certainty).

1 finding from 1 review

Chemotherapy plus involved‐field radiation vs same chemotherapy plus extended‐field radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus involved‐field radiation showed no clear difference in death compared with same chemotherapy plus extended‐field radiation (high certainty).

1 finding from 1 review

Chemotherapy plus lower‐dose radiation vs same chemotherapy plus higher‐dose radiation

Death · Patients with untreated Hodgkin lymphoma (early stages)

Chemotherapy plus lower‐dose radiation showed no clear difference in death compared with same chemotherapy plus higher‐dose radiation (high certainty).

1 finding from 1 review

Prophylactic oxytocin injection (delivered by community health officer) vs control (no injection)

Early infant death (0‐3 days) [ · pregnant women giving birth in non‐facility settings

Prophylactic oxytocin injection (delivered by community health… showed no clear difference in early infant death (0‐3 days) [ compared with control (no injection) (low certainty).

1 finding from 1 review