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Evidence found and GRADE certainty

17 questions · 17 findings · 9 reviews · Haematology

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No studies found 6 · 35.3%GRADE not reported 2 · 11.8%Very low 3 · 17.6%Low 6 · 35.3%Moderate 0 · 0%High 0 · 0%

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

All‐cause mortality within 30 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes all‐cause mortality within 30 days of surgery compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion

Mortality from all causes up to 30 days from study entry · patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs prophylactic platelet transfusions with standard‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with prophylactic platelet transfusions with standard‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs no prophylactic plasma transfusion before surgery/invasive procedures (colloid, crystalloid, placebo, or no treatment)

All‐cause mortality up to 30 days № of participants: 72 (1 RCT) · patients undergoing non‐cardiac surgery/invasive procedures

It is very uncertain whether prophylactic plasma transfusion before surgery/invasive procedures changes all‐cause mortality up to 30 days № of participants: 72 (1 RCT) compared with no prophylactic plasma transfusion before surgery/invasive… (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion at threshold of 10,000 vs higher transfusion threshold (20,000 or 30,000)

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusion at threshold of 10,000 showed no clear difference in mortality from all causes up to 30 days from study entry compared with higher transfusion threshold (20,000 or 30,000) (low certainty).

1 finding from 1 review

Prophylactic platelet transfusions with low‐dose schedule vs high‐dose schedule

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with low‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with high‐dose schedule (low certainty).

1 finding from 1 review

Prophylactic plasma transfusion before surgery/invasive procedures vs alternative haemostatic agents

All‐cause mortality up to 30 days ‐ not reported · patients undergoing non‐cardiac surgery/invasive procedures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic platelet transfusions with high‐dose schedule vs standard‐dose strategies

Mortality from all causes up to 30 days from study entry · People with a haematological disorder

Prophylactic platelet transfusions with high‐dose schedule showed no clear difference in mortality from all causes up to 30 days from study entry compared with standard‐dose schedule (low certainty).

1 finding from 1 review

MSCs vs placebo or control

Death during study period · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their condition.

MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).

1 finding from 1 review