Cochrane · systematic review · CD010981
A therapeutic‐only versus prophylactic platelet transfusion strategy for preventing bleeding in patients with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation
Crighton, GL, Estcourt, LJ, Wood, EM, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 57.1%Very low 0 · 0%Low 1 · 14.3%Moderate 2 · 28.6%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Therapeutic or non‐prophylactic platelet transfusion versus prophylactic platelet transfusion for preventing bleeding in patients with haematological disorders after chemotherapy or stem cell transplantation
Population: patients with haematological disorders undergoing myelosuppressive chemotherapy or stem cell transplantation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least 1 bleeding episode up to 30 days from study entryModified WHO grading scale Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 2 studies · 801 participants | Ungraded |
Number of days with significant bleeding per participant up to 30 days from study entryModified WHO grading scale Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 1 study · 599 participants | Moderate Downgraded: risk of bias |
Number of participants with severe or life‐threatening bleeding up to 30 days from study entryModified WHO grading scale Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | RR 4.91 [0.86, 28.12] | 2 studies · 801 participants | Low Downgraded: risk of bias, imprecision |
Time to first bleeding episode up to 30 days from study entry Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 2 studies · 801 participants | Ungraded |
Mortality from all causes up to 30 days from study entry Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 2 studies · 629 participants | Ungraded |
Number of platelet transfusions per participant up to 30 days from study entry Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 2 studies · 801 participants | Moderate Downgraded: risk of bias |
Quality of life ‐ not reported Therapeutic or non‐prophylactic platelet transfusion vs prophylactic platelet transfusion | no estimate extracted | 0 studies · 0 participants | Ungraded |