Cochrane · systematic review · CD012055
Alternative agents to prophylactic platelet transfusion for preventing bleeding in people with thrombocytopenia due to chronic bone marrow failure: a meta‐analysis and systematic review
Desborough, MJR, Hadjinicolaou, AV, Chaimani, A, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
HaematologyAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 1 · 12.5%Very low 3 · 37.5%Low 3 · 37.5%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Thrombopoietin mimetic versus placebo
Population: People with chronic bone marrow failure
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Number of participants with at least one bleeding episode Thrombopoietin mimetic vs placebo | RR 0.86 [0.56, 1.31] | 4 studies · 206 participants | Low Downgraded: risk of bias |
Number of participants with at least one severe or life‐threatening bleeding episode Thrombopoietin mimetic vs placebo | RR 0.31 [0.04, 2.26] | 1 study · 40 participants | Low Downgraded: risk of bias |
All‐cause mortality Thrombopoietin mimetic vs placebo | RR 0.74 [0.52, 1.05] | 5 studies · 456 participants | Very low Downgraded: risk of bias |
Proportion of participants receiving a platelet transfusion Thrombopoietin mimetic vs placebo | RR 0.76 [0.61, 0.95] | 4 studies · 206 participants | Moderate Downgraded: risk of bias |
Transfusion reactions Thrombopoietin mimetic vs placebo | 0.06 [0, 3.44] | 1 study · 98 participants | Very low Downgraded: risk of bias |
Thromboembolism Thrombopoietin mimetic vs placebo | RR 1.41 [0.39, 5.01] | 5 studies · 456 participants | Very low Downgraded: risk of bias |
Drug reactions Thrombopoietin mimetic vs placebo | RR 1.12 [0.83, 1.51] | 5 studies · 455 participants | Low Downgraded: risk of bias |
Number of red cell transfusions per participant Thrombopoietin mimetic vs placebo | no estimate extracted | 1 study · 98 participants | Ungraded |