MSCs vs placebo or control: Death during study period
MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
MSCs vs control/placebo All‐cause mortality (prophylactic trials) (over duration of trial) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their… MSCs showed no clear difference in all‐cause mortality (prophylactic trials) (over duration of trial) compared with control/placebo (low certainty). Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft‐versus‐host disease in… (2019) · Cochrane Headline outcomes only | HR 0.85 [0.5, 1.42] | 5 studies · 301 participants | Low |
MSCs vs control/placebo All‐cause mortality (therapeutic trials) (over duration of trial) · patients with a haematological condition who receive a haematopoietic stem cell transplant as treatment for their… It is very uncertain whether MSCs changes all‐cause mortality (therapeutic trials) (over duration of trial) compared with control/placebo (very low certainty). Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft‐versus‐host disease in… (2019) · Cochrane Headline outcomes only | HR 1.12 [0.8, 1.56] | 1 study · 244 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Mesenchymal stromal cells as treatment or prophylaxis for acute or chronic graft‐versus‐host disease in haematopoietic stem cell… 2019 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.