Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 72 findings · 36 reviews

No studies found 7 · 9.7%GRADE not reported 2 · 2.8%Very low 22 · 30.6%Low 22 · 30.6%Moderate 13 · 18.1%High 6 · 8.3%

Long‐term red cell transfusion vs hydroxyurea and phlebotomy

All‐cause mortality · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Long‐term red cell transfusion vs no transfusion

All‐cause mortality · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

It is very uncertain whether long‐term red cell transfusion changes all‐cause mortality compared with no transfusion (very low certainty).

1 finding from 1 review

Longer intervals (5‐15 days) (intervention) vs shorter intervals (2‐5 days) (control) between dressing changes

All‐cause mortality · patients with a central venous catheter

Longer intervals (5‐15 days) (intervention) showed no clear difference in all‐cause mortality compared with shorter intervals (2‐5 days) (control) between dressing changes (low certainty).

1 finding from 1 review

Summary of findings for the main comparison. Implantable loop recorder vs conventional diagnostic workup

All‐cause long‐term mortality · people with unexplained recurrent syncope

It is very uncertain whether summary of findings for the main comparison. Implantable loop recorder changes all‐cause long‐term mortality compared with conventional diagnostic workup (very low certainty).

1 finding from 1 review

Tiotropium vs long‐acting beta‐agonists

Mortality (all‐cause) · patients with stable chronic obstructive pulmonary disease and > 10 pack years smoking history

It is very uncertain whether tiotropium changes mortality (all‐cause) compared with long‐acting beta‐agonists (very low certainty).

1 finding from 1 review

Continuation vs discontinuation of antiplatelet therapy

Mortality within the longest · adults undergoing non‐cardiac surgery

Continuation showed no clear difference in all‐cause mortality (at longest compared with discontinuation of antiplatelet therapy (low certainty).

1 finding from 1 review