Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,228 questions · 1,245 findings · 383 reviews

No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%

Antibiotics vs placebo

Discontinuation of medication due to adverse events · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Investigator‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Oral immunosuppressants: oral cyclosporin vs topical betamethasone dipropionate

Number of participants with any adverse event (primary tolerability outcome) · people with hand eczema, continuously for 6 months, significant disability, inadequate response to conventional treatment, confirmation by…

Oral immunosuppressants: oral cyclosporin showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with topical betamethasone dipropionate (moderate certainty).

1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Number of participants with any adverse event (primary tolerability outcome) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with vehicle foam (moderate certainty).

1 finding from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: bronchospasm/treatment discontinued · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: bronchospasm/treatment discontinued compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV regimen administered to infants for 14 weeks changes infants with Probably Related Severe Adverse Events compared with sdNVP plus ZDV (1 week) (very low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV dual regimen administered to infants for 14… changes infants with Probably Related Severe Adverse Events compared with an extended NVP regimen administered to infants (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Vitamin D vs placebo or no intervention

Adverse events ‐ Nephrolithiasis in trials using vitamin D3 combined with calcium · healthy participants or recruited among the general population; individuals diagnosed with a specific disease in a stable phase or with…

Vitamin D may leads to higher adverse events: nephrolithiasis in trials using vitamin… compared with placebo or no intervention (low certainty).

1 finding from 1 review