Question · asked by 1 review
Oral glucosamine hydrochloride/chondroitin sulphate vs placebo: Withdrawals due to adverse events
- Population
- Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of minimum 3 months' duration
- Intervention
- Oral glucosamine hydrochloride/chondroitin sulphate
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral glucosamine hydrochloride/chondroitin sulphate vs Placebo Adverse events (withdrawals due to adverse effects) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to… · 3 months Pharmacological interventions for pain in patients with temporomandibular disorders (2010) · Cochrane All outcomes | Two allergic reactions and one severe abdominal pain led to three withdrawals from the intervention group in the study by Nguyen et al 2001. | 1 study · 45 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes | 2010-08 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.