Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 9 reviews

No studies found 3 · 33.3%GRADE not reported 1 · 11.1%Very low 2 · 22.2%Low 0 · 0%Moderate 2 · 22.2%High 1 · 11.1%

Statins vs placebo

Discontinuation of medication due to adverse events · older people with normal cognitiona

Statins showed no clear difference in adverse events leading to discontinuation of therapy compared with placebo (high certainty).

1 finding from 1 review

Statins with cholesterol supplementation vs cholesterol supplementation only

Statin‐related adverse events · children and adults with Smith‐Lemli‐Opitz syndrome

It is very uncertain whether statins with cholesterol supplementation changes statin‐related adverse events compared with cholesterol supplementation only (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events ‐ at one year · children with familial hypercholesterolemia

The intervention showed no clear difference in adverse events ‐ at one year (moderate certainty).

1 finding from 1 review

Statins vs placebo

Adverse events ‐ Muscle pain · patients with aortic valve stenosis

Statin showed no clear difference in adverse events ‐ Muscle pain compared with placebo (moderate certainty).

1 finding from 1 review

Atorvastatin vs placebo

Serious adverse events or adverse events · people with asthma

The review found no eligible studies for this question.

1 finding from 1 review
  • Statins for asthma 2020 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found