Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,143 questions · 1,168 findings · 420 reviews · Headline outcomes only

No studies found 275 · 23.5%GRADE not reported 89 · 7.6%Very low 344 · 29.5%Low 275 · 23.5%Moderate 137 · 11.7%High 48 · 4.1%

Pre‐hospital cooling vs in‐hospital cooling

Adverse events ‐ re‐arrest after randomization · patients with out‐of‐hospital cardiac arrest

It is very uncertain whether pre‐hospital cooling changes adverse events ‐ re‐arrest after randomization compared with in‐hospital cooling (very low certainty).

1 finding from 1 review

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence

Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).

1 finding from 1 review