Cochrane · systematic review · CD010318
Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus
Liu, Z, Dumville, JC, Hinchliffe, RJ, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
12
No studies
9
Included studies
NR
No studies 9 · 42.9%Ungraded 0 · 0%Very low 6 · 28.6%Low 6 · 28.6%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsNPWT compared with dressings for postoperative foot wounds in people with diabetes mellitus
Population: treating foot wounds in people with diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of wounds healed NPWT vs dressings | RR 1.44 [1.03, 2.01] | 1 study · 162 participants | Low Downgraded: risk of bias, imprecision |
Time to healing NPWT vs dressings | HR 1.91 [1.21, 2.99] | 1 study · 162 participants | Low Downgraded: risk of bias, imprecision |
Amputations NPWT vs dressings | RR 0.38 [0.14, 1.02] | 2 studies · 292 participants | Very low Downgraded: risk of bias, imprecision |
Number of wounds closed or covered with surgery NPWT vs dressings | RR 1.02 [0.95, 1.09] | 1 study · 130 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events NPWT vs dressings | RR 0.96 [0.72, 1.28] | 1 study · 162 participants | Very low Downgraded: risk of bias, imprecision |
Cost‐effectiveness NPWT vs dressings | no estimate extracted | NR | No studies |
Wound recurrence NPWT vs dressings | no estimate extracted | NR | No studies |
NPWT compared with dressings for foot ulcers in people with diabetes mellitus
Population: treating foot wounds in people with diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of wounds healed NPWT vs dressings | RR 1.4 [1.14, 1.72] | 5 studies · 486 participants | Low Downgraded: risk of bias, imprecision |
Time to healing NPWT vs dressings | no estimate extracted | 3 studies · 468 participants | Low Downgraded: risk of bias, imprecision |
Amputations NPWT vs dressings | RR 0.33 [0.15, 0.7] | 3 studies · 441 participants | Low Downgraded: risk of bias, imprecision |
Number of wounds closed or covered with surgery NPWT vs dressings | RR 1.02 [0.85, 1.24] | 3 studies · 129 participants | Low Downgraded: risk of bias, imprecision |
Adverse events NPWT vs dressings | no estimate extracted | NR | No studies |
Cost‐effectiveness NPWT vs dressings | no estimate extracted | NR | No studies |
Wound recurrence NPWT vs dressings | RR 0.5 [0.1, 2.53] | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision |
Low‐pressure compared with high‐pressure NPWT for foot ulcers in people with diabetes mellitus
Population: treating foot wounds in people with diabetes mellitus
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion of wounds healed Low‐pressure vs high‐pressure NPWT | no estimate extracted | NR | No studies |
Time to ulcer healing Low‐pressure vs high‐pressure NPWT | no estimate extracted | NR | No studies |
Amputation Low‐pressure vs high‐pressure NPWT | no estimate extracted | NR | No studies |
Number of wounds closed or covered with surgery Low‐pressure vs high‐pressure NPWT | RR 0.83 [0.47, 1.47] | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Low‐pressure vs high‐pressure NPWT | RR 1.5 [0.28, 8.04] | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Cost‐effectiveness Low‐pressure vs high‐pressure NPWT | no estimate extracted | NR | No studies |
Wound recurrence Low‐pressure vs high‐pressure NPWT | no estimate extracted | NR | No studies |