Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 91 findings · 42 reviews · Headline outcomes only

No studies found 20 · 22%GRADE not reported 3 · 3.3%Very low 21 · 23.1%Low 27 · 29.7%Moderate 17 · 18.7%High 3 · 3.3%

Supervised dosing with a long‐acting medication vs unsupervised consumption

Adverse serious events (any) (number of participants) · patients with opioid dependence

It is very uncertain whether supervised dosing with a long‐acting medication changes adverse serious events (any) (number of participants) compared with unsupervised consumption (very low certainty).

1 finding from 1 review

Intervention not reported

Behavioural outcome: adherence to medication or composite outcome (medication adherence and rate of adverse events) ATCS Plus versus usual care · patients with various conditions or at risk of low adherence to medication or laboratory tests
1 finding from 1 review

Calcineurin inhibitor vs IV cyclophosphamide

Discontinuation of medication due to adverse events · idiopathic steroid‐resistant nephrotic syndrome in children

Calcineurin inhibitor probably leads to lower adverse events: medications ceased due to adverse events compared with IV cyclophosphamide (moderate certainty).

1 finding from 1 review