Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

103 questions · 105 findings · 34 reviews · Hepato-Biliary

No studies found 39 · 37.1%GRADE not reported 5 · 4.8%Very low 54 · 51.4%Low 4 · 3.8%Moderate 3 · 2.9%High 0 · 0%

Intervention vs no intervention or control intervention (control)

Adverse events (number) ‐ interferon‐beta versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐beta versus no intervention compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Intervention vs no intervention or control intervention (control)

Adverse events (proportion) ‐ interferon‐alpha versus no intervention · people with acute hepatitis C infection

It is very uncertain whether intervention changes adverse events (proportion) ‐ interferon‐alpha versus no intervention compared with no intervention or control intervention (control) (very low certainty).

1 finding from 1 review

Intervention vs no intervention or control intervention (control)

Serious adverse events (number) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha · people with acute hepatitis C infection

It is very uncertain whether intervention changes serious adverse events (proportion) ‐ pegylated interferon‐alpha… compared with no intervention or control intervention (control) (very low certainty).

2 findings from 1 review

Intervention vs control

Serious adverse events ‐ Recombinant factor VIIa (rFVIIa) versus control · Patients with liver transplantation.

It is very uncertain whether intervention changes serious adverse events ‐ Recombinant factor VIIa (rFVIIa) versus… compared with control (very low certainty).

1 finding from 1 review

Non‐absorbable disaccharides vs placebo or no intervention

Serious adverse events · prevention and treatment of hepatic encephalopathy in people with cirrhosis

Non‐absorbable disaccharides probably leads to lower serious adverse events compared with placebo/no intervention (moderate certainty).

1 finding from 1 review

Bezafibrate vs no intervention

Adverse events · patients with primary biliary cirrhosis.

It is very uncertain whether bezafibrate changes adverse events compared with no intervention (very low certainty).

1 finding from 1 review