Cochrane · systematic review · CD009146
Hormone replacement for osteoporosis in women with primary biliary cirrhosis
Rudic, JS, Poropat, G, Krstic, MN, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 7 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hormone replacement versus placebo or no intervention for osteoporosis in women with primary biliary cirrhosis
Population: women with primary biliary cirrhosis.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Hormone replacement vs placebo or no intervention | RD 0 | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision |
Fractures Hormone replacement vs placebo or no intervention | no estimate extracted | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Hormone replacement vs placebo or no intervention | RR 5.26 [1.26, 22.04] | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision |
Change in % of lumbar spine bone mineral density (BMD) per year (g/cm2 year‐1) Hormone replacement vs placebo or no intervention | no estimate extracted | 2 studies · 36 participants | Very low Downgraded: risk of bias, imprecision |
Change in % of proximal femur bone mineral density (BMD) per year (g/cm2 year‐1) Hormone replacement vs placebo or no intervention | no estimate extracted | 2 studies · 36 participants | Very low Downgraded: risk of bias, imprecision |
Liver‐related morbidity Hormone replacement vs placebo or no intervention | RR 1.07 [0.15, 7.63] | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision |
Bilirubin (µmol/L) Hormone replacement vs placebo or no intervention | no estimate extracted | 2 studies · 36 participants | Very low Downgraded: risk of bias, imprecision |