Cochrane · systematic review · CD009052
Methods to decrease blood loss and transfusion requirements for liver transplantation
Gurusamy, KS, Pissanou, T, Pikhart, H, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
20
current version
GRADE rated
20
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 20 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Intervention versus control for liver transplantation (mortality, primary graft non‐function, and retransplantation)
Population: Patients with liver transplantation.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
60‐day mortality ‐ Aprotinin versus control Intervention vs control | RR 0.52 [0.18, 1.45] | 3 studies · 280 participants | Very low Downgraded: risk of bias, publication bias |
60‐day mortality ‐ Tranexamic acid versus control Intervention vs control | RR 0.55 [0.17, 1.76] | 3 studies · 139 participants | Very low Downgraded: risk of bias, publication bias |
60‐day mortality ‐ Recombinant factor VIIa (rFVIIa) versus control Intervention vs control | RR 1.51 [0.33, 6.95] | 3 studies · 286 participants | Very low Downgraded: risk of bias, publication bias |
60‐day mortality ‐ Tranexamic acid versus aprotinin Intervention vs control | RR 4.12 [0.71, 23.76] | 2 studies · 178 participants | Very low Downgraded: risk of bias, publication bias |
Primary graft non‐function ‐ Aprotinin versus control Intervention vs control | RR 0.15 [0.02, 1.25] | 2 studies · 217 participants | Very low Downgraded: risk of bias, publication bias |
Retransplantation ‐ Aprotinin versus control Intervention vs control | RR 0.21 [0.02, 1.79] | 2 studies · 217 participants | Very low Downgraded: risk of bias, publication bias |
Retransplantation ‐ Tranexamic acid versus control Intervention vs control | RR 0.79 [0.18, 3.48] | 2 studies · 77 participants | Very low Downgraded: risk of bias, publication bias |
Intervention versus control for liver transplantation (thromboembolic episodes and other serious adverse events)
Population: Patients with liver transplantation.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Thromboembolic episodes ‐ Aprotinin versus control Intervention vs control | RR 0.6 [0.18, 1.96] | 3 studies · 280 participants | Very low Downgraded: risk of bias, publication bias |
Thromboembolic episodes ‐ Tranexamic acid versus control Intervention vs control | RR 2.2 [0.38, 12.64] | 5 studies · 179 participants | Very low Downgraded: risk of bias, publication bias |
Thromboembolic episodes ‐ Recombinant factor VIIa (rFVIIa) versus control Intervention vs control | RR 1.38 [0.65, 2.91] | 2 studies · 266 participants | Very low Downgraded: risk of bias, publication bias |
Serious adverse events ‐ Recombinant factor VIIa (rFVIIa) versus control Intervention vs control | RR 1.3 [0.94, 1.78] | 2 studies · 266 participants | Very low Downgraded: risk of bias, publication bias |
Intervention versus control for liver transplantation (blood loss)
Population: Patients with liver transplantation.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Blood loss ‐ Aprotinin versus control (litre) Intervention vs control | no estimate extracted | 3 studies · 195 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Blood loss ‐ Tranexamic acid versus control (litre) Intervention vs control | no estimate extracted | 2 studies · 65 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Blood loss ‐ Thromboelastography versus control (litre) Intervention vs control | no estimate extracted | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Blood loss ‐ Tranexamic acid versus aprotinin Intervention vs control | no estimate extracted | 2 studies · 71 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Intervention versus control for liver transplantation (red cell or whole blood allogeneic transfusion)
Population: Patients with liver transplantation.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Red cell or whole blood transfusion ‐ Aprotinin versus control Intervention vs control | no estimate extracted | 8 studies · 375 participants | Very low Downgraded: risk of bias, inconsistency, publication bias |
Red cell or whole blood transfusion ‐ Tranexamic acid versus control Intervention vs control | no estimate extracted | 4 studies · 159 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Red cell or whole blood transfusion ‐ Recombinant factor VIIa (rFVIIa) versus control Intervention vs control | no estimate extracted | 2 studies · 221 participants | Very low Downgraded: risk of bias, imprecision, publication bias |
Red cell or whole blood transfusion ‐ Thromboelastography versus control Intervention vs control | no estimate extracted | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Red cell or whole blood transfusion ‐ Tranexamic acid versus aprotinin Intervention vs control | no estimate extracted | 3 studies · 198 participants | Very low Downgraded: risk of bias, imprecision, publication bias |