Cochrane · systematic review · CD009144
Bisphosphonates for osteoporosis in primary biliary cirrhosis
Rudic, JS, Giljaca, V, Krstic, MN, et al. · Cochrane Database of Systematic Reviews · 2011 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
14
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 13 · 92.9%Low 0 · 0%Moderate 1 · 7.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Bisphosphonates compared with placebo or no intervention for osteoporosis in primary biliary cirrhosis
Population: patients with primary biliary cirrhosis.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Bisphosphonates vs placebo or no intervention | RD 0 | 2 studies · 46 participants | Very low Downgraded: risk of bias, imprecision |
Fractures Bisphosphonates vs placebo or no intervention | RR 0.87 [0.29, 2.66] | 3 studies · 106 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Bisphosphonates vs placebo or no intervention | RR 1 [0.49, 2.04] | 2 studies · 46 participants | Very low Downgraded: risk of bias, imprecision |
Lumbar spine bone mineral density (g/cm²) Bisphosphonates vs placebo or no intervention | no estimate extracted | 3 studies · 100 participants | Very low Downgraded: risk of bias, imprecision |
Proximal femur bone mineral density (g/cm²) Bisphosphonates vs placebo or no intervention | no estimate extracted | 3 studies · 100 participants | Very low Downgraded: risk of bias, imprecision |
Serum osteocalcin (ng/ml) Bisphosphonates vs placebo or no intervention | no estimate extracted | 3 studies · 100 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
The urinary amino telopeptides of collagen I (NTx) (nmol bone collagen equivalents/mmol creatinine) Bisphosphonates vs placebo or no intervention | no estimate extracted | 2 studies · 88 participants | Moderate Downgraded: risk of bias, imprecision |
Bisphosphonates compared with another bisphosphonate for osteoporosis in primary biliary cirrhosis
Population: patients with primary biliary cirrhosis.
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality Bisphosphonates vs another bisphosphonate | no estimate extracted | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision |
Fractures Bisphosphonates vs another bisphosphonate | RR 0.95 [0.18, 5.06] | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Bisphosphonates vs another bisphosphonate | RR 0.95 [0.31, 2.94] | 2 studies · 62 participants | Very low Downgraded: risk of bias, imprecision |
Lumbar spine bone mineral density (g/cm²) Bisphosphonates vs another bisphosphonate | no estimate extracted | 2 studies · 50 participants | Very low Downgraded: risk of bias, imprecision |
Proximal femur bone mineral density (g/cm²) Bisphosphonates vs another bisphosphonate | no estimate extracted | 2 studies · 49 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
The procollagen type I N‐terminal propeptide (PINP) (ng/ml) Bisphosphonates vs another bisphosphonate | no estimate extracted | 2 studies · 48 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
The urinary amino telopeptides of collagen I (NTx) (nmol bone collagen equivalents /mmol creatinine) Bisphosphonates vs another bisphosphonate | no estimate extracted | 2 studies · 46 participants | Very low Downgraded: risk of bias, imprecision |