Cochrane · systematic review · CD011644
Pharmacological interventions for acute hepatitis C infection
Kalafateli, M, Buzzetti, E, Thorburn, D, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
9
No studies
5
Included studies
NR
No studies 5 · 35.7%Ungraded 0 · 0%Very low 9 · 64.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsIntervention versus no intervention or control intervention (control) for acute hepatitis C infection: primary outcomes
Population: people with acute hepatitis C infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Serious adverse events (proportion) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha Intervention vs no intervention or control intervention (control) | OR 1.72 [0.7, 4.21] | 2 studies · 237 participants | Very low Downgraded: risk of bias, imprecision |
Serious adverse events (number) ‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha Intervention vs no intervention or control intervention (control) | Rate ratio 2.74 [1.4, 5.33] | 2 studies · 237 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (proportion) ‐ interferon‐alpha versus no intervention Intervention vs no intervention or control intervention (control) | OR 203 [9.01, 4574.81] | 1 study · 33 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (proportion) ‐ interferon‐beta versus no intervention Intervention vs no intervention or control intervention (control) | OR 27.88 [1.48, 526.12] | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events (number) ‐ interferon‐beta versus no intervention Intervention vs no intervention or control intervention (control) | OR 17 [0.98, 294.53] | 1 study · 40 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Intervention vs no intervention or control intervention (control) | no estimate extracted | NR | No studies |
Intervention versus no intervention or control intervention (control) for acute hepatitis C infection: secondary outcomes
Population: people with acute hepatitis C infection
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Liver transplantation Intervention vs no intervention or control intervention (control) | no estimate extracted | NR | No studies |
Decompensated liver disease Intervention vs no intervention or control intervention (control) | no estimate extracted | NR | No studies |
Cirrhosis Intervention vs no intervention or control intervention (control) | no estimate extracted | NR | No studies |
Hepatocellular carcinoma Intervention vs no intervention or control intervention (control) | no estimate extracted | NR | No studies |
Chronic HCV infection†‐ interferon‐alpha versus no intervention Intervention vs no intervention or control intervention (control) | OR 0.27 [0.09, 0.76] | 3 studies · 99 participants | Very low Downgraded: risk of bias, imprecision |
Chronic HCV infection†‐ interferon‐beta versus no intervention Intervention vs no intervention or control intervention (control) | OR 0.07 [0, 1.24] | 3 studies · 90 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Chronic HCV infection†‐ MTH‐68/B vaccine versus no intervention Intervention vs no intervention or control intervention (control) | OR 0.28 [0.05, 1.65] | 1 study · 41 participants | Very low Downgraded: risk of bias, imprecision |
Chronic HCV infection†‐ pegylated interferon‐alpha plus ribavirin versus pegylated interferon‐alpha Intervention vs no intervention or control intervention (control) | OR 0.86 [0.41, 1.79] | 2 studies · 237 participants | Very low Downgraded: risk of bias, imprecision |