Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 7 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 7 · 38.9%GRADE not reported 2 · 11.1%Very low 2 · 11.1%Low 5 · 27.8%Moderate 2 · 11.1%High 0 · 0%

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review

Exercise vs no intervention

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review
  • Exercise for haemophilia 2016 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Side effects or other adverse events · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… showed no clear difference in side effects or other adverse events compared with placebo, no intervention or usual care (with or without placebo) (low certainty).

1 finding from 1 review