Cochrane · systematic review · CD002768

Physical activity and exercise training in cystic fibrosis

Radtke, T, Smith, S, Nevitt, SJ, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library

Cystic Fibrosis and Genetic Disorders2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 2 · 28.6%High 1 · 14.3%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Physical activity compared with no physical activity for cystic fibrosis

Population: adults and children with cystic fibrosis

7 questions

Outcome	Effect	Evidence	Status / GRADE
Exercise capacity: change in VO2 peak (mL/min per kg bodyweight) Active intervention: > 6 months Physical activity vs no physical activity	no estimate extracted	6 studies · 348 participants	Moderate Downgraded: risk of bias, imprecision, inconsistency
FEV1 % predicted (change from baseline) Active intervention: > 6 months Physical activity vs no physical activity	no estimate extracted	6 studies · 367 participants	Low Downgraded: risk of bias, imprecision, inconsistency
HRQoL: change in CFQ‐R physical functioning domain score Active intervention: > 6 months Physical activity vs no physical activity	no estimate extracted	4 studies · 247 participants	Low Downgraded: risk of bias
HRQoL: change in CFQ‐R respiratory symptoms domain score Active intervention: > 6 months Physical activity vs no physical activity	no estimate extracted	4 studies · 251 participants	Low Downgraded: risk of bias
Pulmonary exacerbations: number of exacerbations occurring in the study period Active intervention: 12 months Physical activity vs no physical activity	no estimate extracted	1 study · 117 participants	High
Diabetic control: change in blood glucose levels at rest, at 60 and 120 minutes after a glucose ingestion (mmol/L) Active intervention: 9 months Physical activity vs no physical activity	no estimate extracted	1 study · 91 participants	Moderate Downgraded: imprecision
Adverse events: number of adverse events Active intervention: 12 months Physical activity vs no physical activity	no estimate extracted	2 studies · 156 participants	Low Downgraded: risk of bias, imprecision