Cochrane · systematic review · CD002768
Physical activity and exercise training in cystic fibrosis
Radtke, T, Smith, S, Nevitt, SJ, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 57.1%Moderate 2 · 28.6%High 1 · 14.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyPhysical activity compared with no physical activity for cystic fibrosis
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exercise capacity: change in VO2 peak (mL/min per kg bodyweight) Active intervention: > 6 months Physical activity vs no physical activity | no estimate extracted | 6 studies · 348 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
FEV1 % predicted (change from baseline) Active intervention: > 6 months Physical activity vs no physical activity | no estimate extracted | 6 studies · 367 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
HRQoL: change in CFQ‐R physical functioning domain score Active intervention: > 6 months Physical activity vs no physical activity | no estimate extracted | 4 studies · 247 participants | Low Downgraded: risk of bias |
HRQoL: change in CFQ‐R respiratory symptoms domain score Active intervention: > 6 months Physical activity vs no physical activity | no estimate extracted | 4 studies · 251 participants | Low Downgraded: risk of bias |
Pulmonary exacerbations: number of exacerbations occurring in the study period Active intervention: 12 months Physical activity vs no physical activity | no estimate extracted | 1 study · 117 participants | High |
Diabetic control: change in blood glucose levels at rest, at 60 and 120 minutes after a glucose ingestion (mmol/L) Active intervention: 9 months Physical activity vs no physical activity | no estimate extracted | 1 study · 91 participants | Moderate Downgraded: imprecision |
Adverse events: number of adverse events Active intervention: 12 months Physical activity vs no physical activity | no estimate extracted | 2 studies · 156 participants | Low Downgraded: risk of bias, imprecision |
Summary of findings ‐ Aerobic training versus no physical training
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exercise capacity: change in VO2 peak during maximal exercise (mL/min per kg body weight) Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | 4 studies · 170 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Pulmonary function: change in FEV1 (% predicted) Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | 5 studies · 187 participants | Low Downgraded: risk of bias, imprecision, indirectness |
HRQoL: CFQ Quality of Well‐being Scale and perceived 'positive effects.' Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | 3 studies · 143 participants | Low Downgraded: risk of bias, imprecision, indirectness |
CF‐related mortality Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | NR | No studies |
Pulmonary exacerbations: number of hospitalisations and number of days in hospital Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | 1 study · 65 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Diabetic control Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | NR | No studies |
Adverse events Summary of findings ‐ Aerobic training vs no physical training | no estimate extracted | 2 studies · 71 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Summary of findings ‐ Anaerobic training versus no physical training
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exercise capacity: change in VO2 peak during maximal exercise (mL/min per kg BW) Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | 3 studies · 86 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Pulmonary function: change in FEV1 (% predicted) Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | 3 studies · 86 participants | Low Downgraded: risk of bias, imprecision, indirectness |
HRQoL: Quality of Well‐being Scale or HRQoL scale physical function Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | 2 studies · 64 participants | Low Downgraded: risk of bias, imprecision, indirectness |
CF‐related mortality Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | NR | No studies |
Pulmonary exacerbations Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | NR | No studies |
Diabetic control Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | NR | No studies |
Adverse events Summary of findings ‐ Anaerobic training vs no physical training | no estimate extracted | 1 study · 22 participants | Moderate Downgraded: risk of bias, imprecision, indirectness |
Summary of findings ‐ Combined aerobic and anaerobic training versus no training
Population: adults and children with cystic fibrosis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Exercise capacity: change in VO2 peak during maximal exercise (mL/min per kg body weight) Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | 2 studies · 52 participants | Low Downgraded: risk of bias, imprecision |
Pulmonary function: change in FEV1 (% predicted) or mL Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | 3 studies · 103 participants | Low Downgraded: risk of bias, imprecision |
HRQoL: CFQ, Medical Outcomes Study‐36 Item Short‐Form Health Survey, SF‐36 Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | 3 studies · 93 participants | Very low Downgraded: risk of bias, imprecision |
CF‐related mortality Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | NR | No studies |
Pulmonary exacerbations Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | NR | No studies |
Diabetic control Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | 1 study · 14 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events Summary of findings ‐ Combined aerobic and anaerobic training vs no training | no estimate extracted | NR | No studies |