Question · asked by 1 review
Hydroxyurea vs placebo: Serious adverse events
- Population
- people with sickle cell disease
- Intervention
- Hydroxyurea
- Comparison
- placebo
- Outcome
- Serious adverse events
Hydroxyurea showed no clear difference in serious adverse events compared with placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Hydroxyurea vs placebo Serious adverse events · people with sickle cell disease Hydroxyurea showed no clear difference in serious adverse events compared with placebo (low certainty). Interventions for chronic kidney disease in people with sickle cell disease (2023) · Cochrane Headline outcomes only | RR 0.39 [0.13, 1.16] | 1 study · 193 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for chronic kidney disease in people with sickle cell disease 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.