Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 13 reviews

No studies found 6 · 19.4%GRADE not reported 5 · 16.1%Very low 11 · 35.5%Low 7 · 22.6%Moderate 2 · 6.5%High 0 · 0%

Acetaminophen plus Diphenhydramine vs placebo

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydramine led to lower adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion)

Adverse events · patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions

Acetaminophen plus Diphenhydrammine led to lower adverse events compared with placebo (Unit of randomisation: transfusion); GRADE not reported.

1 finding from 1 review

Tramadol in combination with acetaminophen vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

Adverse events · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
1 finding from 1 review