Cochrane · systematic review · CD007539
Pharmacological interventions for the prevention of allergic and febrile non‐haemolytic transfusion reactions
Martí‐Carvajal, AJ, Solà, I, González, LE, et al. · Cochrane Database of Systematic Reviews · 2010 · Cochrane Library
InjuriesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 6 · 60%Very low 1 · 10%Low 3 · 30%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Acetaminophen plus Diphenhydramine versus placebo for preventing allergic and febrile non‐haemolytic transfusion reactions (Unit of randomisation: Patient).
Population: patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Febrile reactions (fever with or without chills, chills with or without rigors) ‐ Intention‐to treat analysis Acetaminophen plus Diphenhydramine vs placebo | RR 0.52 [0.21, 1.25] | 1 study · 334 participants | Low Downgraded: risk of bias, imprecision |
Anaphylatic reactions ‐ not reported Acetaminophen plus Diphenhydramine vs placebo | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Death ‐ not reported Acetaminophen plus Diphenhydramine vs placebo | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Adverse events Acetaminophen plus Diphenhydramine vs placebo | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Allergic reactions (urticaria with or without pruritus) ‐ Intention‐to treat analysis Acetaminophen plus Diphenhydramine vs placebo | RR 1.45 [0.78, 2.72] | 1 study · 334 participants | Very low Downgraded: risk of bias, imprecision |
Acetaminophen plus Diphenhydrammine versus placebo (Unit of randomisation: transfusion) for requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
Population: patients with requirement of prophylaxis to avoid allergic and febrile non‐haemolytic transfusion reactions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Fever ‐ Per protocol analysis Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion) | RR 1.77 [0.57, 5.49] | 1 study · 98 participants | Low Downgraded: risk of bias, imprecision |
Anaphylatic reactions ‐ not reported Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion) | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Hives ‐ Per protocol analysis Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion) | RR 0.13 [0.01, 2.39] | 1 study · 98 participants | Low Downgraded: risk of bias |
Death ‐ not reported Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion) | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |
Adverse events Acetaminophen plus Diphenhydrammine vs placebo (Unit of randomisation: transfusion) | RR 0 [0, 0] | 0 studies · 0 participants | Ungraded |