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What do systematic reviews say?

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Evidence found and GRADE certainty

1,228 questions · 1,245 findings · 383 reviews

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No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%

Summary of findings table ‐ Selective prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Indicated prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders
2 findings from 1 review

Summary of findings table ‐ Promotion/universal prevention interventions vs control group

Adverse events at study endpoint · preventing mental disorders
2 findings from 1 review

Antidepressants vs placebo

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).

1 finding from 1 review

Assistive technology for vision improvement interventions vs usual care or attention control

Adverse events Falls while switching glasses · Older people living in the community

Assistive technology for vision improvement interventions showed no clear difference in adverse events Falls while switching glasses compared with usual care or attention control (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Anxiety: GAD‐7 (Spitzer 2006) compared with usual care (low certainty).

1 finding from 1 review

Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment

Adverse events (any type) and safety of sealant · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

The review found no eligible studies for this question.

1 finding from 1 review

Lay health worker‐led psychological interventions vs usual care

Adverse events RR < 1 indicates lower risk of adverse events · adults with common mental disorders

Lay health worker‐led psychological interventions may leads to lower adverse events RR < 1 indicates lower risk of adverse events compared with usual care (low certainty).

1 finding from 1 review

Psychological interventions vs usual care

Treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) · children, adolescents or adults with CF

Summary of findings: psychological interventions showed no clear difference in treatment‐related adverse events Depression PHQ‐8 (Kroenke 2009) compared with usual care (low certainty).

1 finding from 1 review