Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Intervention not reported

Adverse events related to RIPC · patients undergoing a surgical intervention that induces kidney injury

The intervention showed no clear difference in adverse events related to RIPC (high certainty).

1 finding from 1 review

Amantidine vs antidepressants

Risk for at least one adverse event per patient · patients with the treatment of cocaine dependence

Amantidine showed no clear difference in adverse events as N of participants with at least one adverse event compared with antidepressants (low certainty).

1 finding from 1 review

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN vs CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐ medium term (3‐12 months)

Adverse events: 1a. Serious adverse event ‐ switching to aripiprazole · patients with people with schizophrenia who have neuroleptic‐induced weight or metabolic problems

SWITCHING ‐ NEW ANTIPSYCHOTIC REGIMEN showed no clear difference in adverse events: 1a. Serious adverse event ‐ switching to aripiprazole compared with CONTINUATION ON PREVIOUS REGIMEN: 1b. NEW ATYPICAL from OLANZAPINE ‐… (low certainty).

1 finding from 1 review

Hysterectomy with opportunistic salpingectomy vs hysterectomy without opportunistic salpingectomy

Surgery‐related adverse events: short‐term postoperative complications · premenopausal women undergoing hysterectomy for benign gynaecological indications

It is very uncertain whether hysterectomy with opportunistic salpingectomy changes surgery‐related adverse events: short‐term postoperative complications compared with hysterectomy without opportunistic salpingectomy (very low certainty).

1 finding from 1 review

Efficacy and safety of a first dose of whole‐cell pertussis vaccine vs a first dose of acellular pertussis vaccine

All‐cause serious adverse events · the promotion of growth and prevention of infections in infants less than six months of age

Efficacy and safety of a first dose of whole‐cell pertussis vaccine showed no clear difference in all‐cause serious adverse events compared with a first dose of acellular pertussis vaccine (moderate certainty).

1 finding from 1 review

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review