Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

419 questions · 420 findings · 128 reviews

No studies found 71 · 16.9%GRADE not reported 69 · 16.4%Very low 96 · 22.9%Low 116 · 27.6%Moderate 63 · 15%High 5 · 1.2%

Chloral hydrate oral (50 mg/kg) vs melatonin oral

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with melatonin oral (low certainty).

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg or 100 mg/kg) vs dexmedetomidine oral (2 µg/kg or 3 µg/kg)

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg or 100 mg/kg) may leads to higher number of children with clinical adverse events (any) compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (low certainty).

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Oral antibiotics vs placebo

Adverse events at 1 month · adult participants with chronic blepharitis

It is very uncertain whether oral antibiotics changes adverse events at 1 month compared with placebo (very low certainty).

1 finding from 1 review