Findings

What do systematic reviews say?

31 questions · 31 findings · 13 reviews

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No studies found 6 · 19.4%GRADE not reported 5 · 16.1%Very low 11 · 35.5%Low 7 · 22.6%Moderate 2 · 6.5%High 0 · 0%

Intervention not reported

All adverse events · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 283 participants
Moderate

Oral tramadol vs oral morphine

Other adverse events · people with cancer pain

1 finding from 1 review

Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Serious adverse events · people with cancer pain

1 finding from 1 review

Oral paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 93 participants
Very low

Paracetamol 500 mg to 650 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Paracetamol 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol alone, paracetamol plus codeine, or paracetamol plus dihydrocodeine vs placebo

Serious adverse events · adults with chronic neuropathic pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Serious adverse events · Adults with cancer pain

1 finding from 1 review

Codeine, alone and with paracetamol (acetaminophen), for cancer pain 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Tramadol vs paracetamol

Withdrawals due to adverse events · patients with osteoarthritis

It is very uncertain whether tramadol alone changes number of participants who withdrew due to adverse events compared with acetaminophen (very low certainty).

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
RR 5 [0.27, 92.62]
1 study · 20 participants
Very low

Tramadol vs paracetamol

Number of participants experiencing any serious adverse events · patients with osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral tramadol vs oral morphine

Serious adverse events (death) · people with cancer pain

1 finding from 1 review

Tramadol with or without paracetamol (acetaminophen) for cancer pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 280 participants
Very low

Intervention not reported

Withdrawal due to adverse events Methotrexate discontinuation · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 632 participants
Low