Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

458 questions · 473 findings · 205 reviews

No studies found 128 · 27.1%GRADE not reported 49 · 10.4%Very low 142 · 30%Low 106 · 22.4%Moderate 36 · 7.6%High 12 · 2.5%

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) inactivated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The intervention showed no clear difference in non‐serious systemic adverse events (low risk of bias) inactivated… (high certainty).

1 finding from 1 review

Intervention not reported

Non‐serious local adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Non‐serious systemic adverse events (low risk of bias) live attenuated HAV vaccine ICH‐GCP 1997 · patients with preventing hepatitis A.

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events ‐ Ectopic pregnancy Melatonin lower dose versus melatonin higher dose№ of participants: 120(1 RCT) · women with subfertility
1 finding from 1 review

Timing of wound closure (immediate vs delayed)

Adverse events ‐ superficial infection · adults with open long bone fractures of the upper and lower limbs

It is very uncertain whether timing of wound closure (immediate changes adverse events ‐ superficial infection compared with delayed) (very low certainty).

1 finding from 1 review

Paracetamol vs placebo

Serious adverse events Up to 12 weeks' · Patients with acute low‐back pain

Paracetamol showed no clear difference in serious adverse events Up to 12 weeks' compared with placebo (moderate certainty).

1 finding from 1 review

CBT vs TAU

AEs · chronic pain (excluding headache) in adults
2 findings from 1 review · compare the 2 reviews

Intervention not reported

There was no evidence of differences in the number of serious adverse events for any of the comparisons Quality of evidence = very low1,2,3. · people undergoing liver resection

The review found no eligible studies for this question.

1 finding from 1 review

Oral paracetamol vs placebo

Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

1 finding from 1 review

Intervention not reported

There was no evidence of differences in the proportion of participants experiencing serious adverse events (for any of the comparisons Quality of evidence = very low1,2,3. · people undergoing liver resection
1 finding from 1 review

Interdisciplinary enhanced rehabilitation (inpatient and community rehabilitation) vs conventional rehabilitation

Adverse effects (fall down) · adults with dementia following hip fracture surgery

It is very uncertain whether interdisciplinary enhanced rehabilitation (inpatient and community… changes adverse events (incidence of falls at 12 months) compared with conventional rehabilitation (very low certainty).

1 finding from 1 review

Geriatrician‐led inpatient management vs orthopaedic‐led inpatient management

Adverse events (delirium during hospitalisation) · adults with dementia following hip fracture surgery

It is very uncertain whether geriatrician‐led inpatient management changes adverse events (delirium during hospitalisation) compared with orthopaedic‐led inpatient management (very low certainty).

1 finding from 1 review

Anti‐TNF disease activity–guided dose tapering vs anti‐TNF continuation

Withdrawals due to adverse events not measured · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

The review found no eligible studies for this question.

1 finding from 1 review