Cochrane · systematic review · CD013555
Timing of antibiotic administration, wound debridement, and the stages of reconstructive surgery for open long bone fractures of the upper and lower limbs
Chan, JK-K, Aquilina, AL, Lewis, SR, et al. · Cochrane Database of Systematic Reviews · 2022 · Cochrane Library
Bone, Joint and Muscle TraumaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
4
No studies
10
Included studies
NR
No studies 10 · 71.4%Ungraded 0 · 0%Very low 4 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Duration of prophylactic antibiotic treatment for open long bone fractures of the upper and lower limbs
Population: adults with open long bone fractures; study in the review included only Gustilo II open tibia fractures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Limb function at 6 or 12 months | no estimate extracted | NR | No studies |
HRQoL at 6 or 12 months | no estimate extracted | NR | No studies |
Deep surgical site infection at 30 days or 90 days, or time points reported by study authors | no estimate extracted | NR | No studies |
Delayed or non‐union at time points reported by study authors | no estimate extracted | NR | No studies |
Unplanned operations at 12 months | no estimate extracted | NR | No studies |
Adverse events: superficial infection | RR 1.19 [0.49, 2.87] | 1 study · 77 participants | Very low Downgraded: risk of bias, imprecision |
Return to work by 12 months | no estimate extracted | NR | No studies |
Timing of wound closure (immediate versus delayed) for open long bone fractures of the upper and lower limbs
Population: adults with open long bone fractures of the upper and lower limbs
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Limb function at 6 or 12 months Timing of wound closure (immediate vs delayed) | no estimate extracted | NR | No studies |
HRQoL at 6 or 12 months Timing of wound closure (immediate vs delayed) | no estimate extracted | NR | No studies |
Deep surgical site infection Timing of wound closure (immediate vs delayed) | RR 0.82 [0.37, 1.8] | 2 studies · 458 participants | Very low Downgraded: risk of bias, imprecision |
Delayed union or non‐union Timing of wound closure (immediate vs delayed) | RR 1.13 [0.83, 1.55] | 1 study · 387 participants | Very low Downgraded: risk of bias, imprecision |
Unplanned operations at 12 months Timing of wound closure (immediate vs delayed) | no estimate extracted | NR | No studies |
Adverse events ‐ superficial infection Timing of wound closure (immediate vs delayed) | RR 6.45 [0.35, 120.43] | 1 study · 71 participants | Very low Downgraded: risk of bias, imprecision |
Return to work by 12 months Timing of wound closure (immediate vs delayed) | no estimate extracted | NR | No studies |