Antidepressants vs placebo
It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).
- RR 0.88 [0.64, 1.21]2 studies · 167 participantsVery low
It is very uncertain whether antidepressant changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with placebo (very low certainty).
The review found no eligible studies for this question.
Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).
The review found no eligible studies for this question.
It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).
Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).
Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).
Brexpiprazole leads to higher number of dropouts due to adverse effects at 8 weeks compared with antidepressive agents (high certainty).
Brexpiprazole probably leads to higher adverse effects: akathisia (followed up until the end of the longest compared with antidepressive agents (moderate certainty).
Brexpiprazole probably leads to higher adverse effects: weight gain (followed up until the end of the longest compared with antidepressive agents (moderate certainty).
The review found no eligible studies for this question.
S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Tricyclic antidepressants showed no clear difference in adverse effects (drop‐outs due to adverse effects4) compared with another medication (low certainty).