Cochrane · systematic review · CD001026
Antidepressants plus benzodiazepines for adults with major depression
Ogawa, Y, Takeshima, N, Hayasaka, Y, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 16.7%Low 2 · 33.3%Moderate 3 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressants plus benzodiazepines compared to antidepressants alone for major depression in adults
Population: people with major depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Depression severity: early phase (2 weeks, range 1–4 weeks) Antidepressants plus benzodiazepines vs antidepressants alone | no estimate extracted | 10 studies · 598 participants | Moderate Downgraded: risk of bias |
Depression severity: acute phase (8 weeks, range 5–12 weeks) Antidepressants plus benzodiazepines vs antidepressants alone | no estimate extracted | 7 studies · 347 participants | Low Downgraded: risk of bias, imprecision |
Depression severity: continuous phase (> 12 weeks) Antidepressants plus benzodiazepines vs antidepressants alone | no estimate extracted | 1 study · 50 participants | Low Downgraded: risk of bias, imprecision |
Acceptability of treatment (dropout for any reason) Antidepressants plus benzodiazepines vs antidepressants alone | RR 0.76 [0.54, 1.07] | 10 studies · 731 participants | Moderate Downgraded: risk of bias |
Anxiety severity: early phase (2 weeks, range 1–4 weeks) Antidepressants plus benzodiazepines vs antidepressants alone | no estimate extracted | 3 studies · 129 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse effects (dropouts) Antidepressants plus benzodiazepines vs antidepressants alone | RR 0.54 [0.32, 0.9] | 10 studies · 731 participants | Moderate Downgraded: risk of bias |