Cochrane · systematic review · CD013866
Brexpiprazole versus placebo or other antidepressive agents for treating depression
Ralovska, S, Koychev, I, Marinov, P, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 28.6%High 5 · 71.4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Brexpiprazole compared to antidepressive agents for the treatment of depression
Population: participants of any age with a primary diagnosis of major depressive disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response to treatment at 8 weeks Brexpiprazole vs antidepressive agents | OR 1.47 [1.23, 1.75] | 8 studies · 3409 participants | High |
Number of dropouts due to any cause at 8 weeks Brexpiprazole vs antidepressive agents | OR 1.37 [1.02, 1.83] | 7 studies · 2523 participants | High |
Number of dropouts due to adverse effects at 8 weeks Brexpiprazole vs antidepressive agents | OR 2.88 [1.37, 6.05] | 6 studies · 2472 participants | High |
Remission rates at 8 weeks Brexpiprazole vs antidepressive agents | OR 1.46 [1.19, 1.79] | 7 studies · 3358 participants | High |
Change in depressive symptoms at 8 weeks Brexpiprazole vs antidepressive agents | MD 1.39 | 8 studies · 3263 participants | High |
Adverse effects: akathisia (followed up until the end of the longest Brexpiprazole vs antidepressive agents | OR 2.95 [2.06, 4.21] | 7 studies · 3358 participants | Moderate Downgraded: indirectness |
Adverse effects: weight gain (followed up until the end of the longest Brexpiprazole vs antidepressive agents | OR 3.14 [2.19, 4.49] | 9 studies · 3424 participants | Moderate Downgraded: indirectness |