Tricyclic antidepressants vs placebo: Withdrawals due to adverse events
- Population
- adults with panic disorder
- Intervention
- Tricyclic antidepressants
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tricyclic antidepressants vs placebo Number of dropouts due to adverse effects · adults with panic disorder Tricyclic antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty). Antidepressants versus placebo for panic disorder in adults (2018) · Cochrane Headline outcomes only | RR 1.97 [1.33, 2.91] | 10 studies · 1641 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Tricyclic antidepressants vs SSRI · adults with panic disorder · 1 review
- Tricyclic antidepressants vs control · patients with pain management in rheumatoid arthritis · 1 review
- Tricyclic antidepressants vs MAOI · adults with panic disorder · 1 review
- Tricyclic antidepressants vs benzodiazepines · adults with panic disorder · 1 review
- Tricyclic antidepressants vs placebo · somatoform disorders in adults · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.