Cochrane · systematic review · CD011567
Antidepressants and benzodiazepines for panic disorder in adults
Bighelli, I, Trespidi, C, Castellazzi, M, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
42
current version
GRADE rated
38
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 4 · 9.5%Very low 10 · 23.8%Low 19 · 45.2%Moderate 6 · 14.3%High 3 · 7.1%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antidepressants compared to benzodiazepines for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond Antidepressants vs benzodiazepines | RR 0.99 [0.67, 1.47] | 2 studies · 215 participants | Low |
total number of dropouts Antidepressants vs benzodiazepines | RR 1.64 [1.03, 2.63] | 7 studies · 1449 participants | Very low |
failure to remit Antidepressants vs benzodiazepines | RR 1.18 [1.01, 1.37] | 3 studies · 1002 participants | Moderate |
panic symptoms ‐ endpoint score Antidepressants vs benzodiazepines | no estimate extracted | 3 studies · 1144 participants | Very low |
panic symptoms ‐mean change Antidepressants vs benzodiazepines | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision, inconsistency |
number of dropouts due to adverse effects Antidepressants vs benzodiazepines | RR 1.72 [1.03, 2.87] | 3 studies · 1002 participants | Low |
TCAs compared to benzodiazepines for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond TCAs vs benzodiazepines | RR 1.02 [0.63, 1.67] | 1 study · 61 participants | Very low Downgraded: imprecision |
total number of dropouts TCAs vs benzodiazepines | RR 1.67 [0.93, 2.99] | 6 studies · 1295 participants | Very low |
failure to remit TCAs vs benzodiazepines | RR 1.19 [1, 1.41] | 2 studies · 848 participants | Moderate |
panic symptoms ‐ endpoint score TCAs vs benzodiazepines | no estimate extracted | 2 studies · 998 participants | Very low |
panic symptoms ‐ mean change TCAs vs benzodiazepines | no estimate extracted | 1 study · 44 participants | Low Downgraded: imprecision, inconsistency |
number of dropouts due to adverse effects TCAs vs benzodiazepines | RR 2.1 [1.13, 3.93] | 2 studies · 848 participants | Low |
SSRIs compared to benzodiazepines for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond SSRIs vs benzodiazepines | RR 0.93 [0.48, 1.8] | 1 study · 154 participants | Very low Downgraded: imprecision |
total number of dropouts SSRIs vs benzodiazepines | RR 1.71 [1.03, 2.84] | 1 study · 154 participants | Very low Downgraded: imprecision |
failure to remit SSRIs vs benzodiazepines | RR 1.12 [0.79, 1.59] | 1 study · 154 participants | Very low Downgraded: imprecision |
panic symptoms SSRIs vs benzodiazepines | no estimate extracted | 1 study · 146 participants | Low Downgraded: imprecision |
number of dropouts due to adverse effects SSRIs vs benzodiazepines | RR 1.2 [0.55, 2.61] | 1 study · 154 participants | Very low Downgraded: imprecision |
TCAs compared to SSRI for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond TCAs vs SSRI | RR 1.08 [0.71, 1.66] | 4 studies · 438 participants | Low Downgraded: imprecision, inconsistency |
total number of dropouts TCAs vs SSRI | RR 0.98 [0.65, 1.48] | 7 studies · 928 participants | Low Downgraded: imprecision, inconsistency |
failure to remit TCAs vs SSRI | RR 0.89 [0.63, 1.26] | 5 studies · 475 participants | Moderate Downgraded: inconsistency |
panic symptoms TCAs vs SSRI | no estimate extracted | 4 studies · 243 participants | Very low Downgraded: imprecision, inconsistency |
number of dropouts due to adverse effects TCAs vs SSRI | RR 1.43 [0.82, 2.48] | 5 studies · 476 participants | Low Downgraded: imprecision |
TCA compared to MAOI for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond TCA vs MAOI | RR 0.59 [0.28, 1.26] | 1 study · 135 participants | Low Downgraded: imprecision |
total number of dropouts TCA vs MAOI | RR 0.84 [0.61, 1.17] | 2 studies · 228 participants | Moderate |
failure to remit TCA vs MAOI | no estimate extracted | 0 studies · 0 participants | Ungraded |
panic symptoms TCA vs MAOI | no estimate extracted | 1 study · 135 participants | Low Downgraded: imprecision |
number of dropouts due to adverse events TCA vs MAOI | RR 1.27 [0.5, 3.21] | 1 study · 135 participants | Low Downgraded: imprecision |
SSRIs compared to MAOIs for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond SSRIs vs MAOIs | RR 1.12 [0.83, 1.52] | 2 studies · 396 participants | Moderate Downgraded: imprecision |
total number of dropouts SSRIs vs MAOIs | RR 1 [0.07, 14.55] | 1 study · 30 participants | Low Downgraded: imprecision |
failure to remit SSRIs vs MAOIs | RR 0.93 [0.74, 1.17] | 1 study · 366 participants | Moderate Downgraded: imprecision |
panic symptoms SSRIs vs MAOIs | no estimate extracted | 0 studies · 0 participants | Ungraded |
number of dropouts due to adverse events SSRIs vs MAOIs | RR 1.26 [0.59, 2.7] | 1 study · 366 participants | Low Downgraded: imprecision |
SSRIs compared to SNRIs for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond SSRIs vs SNRIs | RR 0.96 [0.75, 1.23] | 2 studies · 991 participants | High |
total number of dropouts SSRIs vs SNRIs | RR 1.11 [0.74, 1.65] | 2 studies · 991 participants | Low Downgraded: imprecision, inconsistency |
failure to remit SSRIs vs SNRIs | RR 1.05 [0.91, 1.21] | 2 studies · 991 participants | High |
panic symptoms SSRIs vs SNRIs | no estimate extracted | 2 studies · 945 participants | High |
number of dropouts due to adverse effects SSRIs vs SNRIs | RR 1.86 [0.49, 7.05] | 2 studies · 991 participants | Low Downgraded: imprecision, inconsistency |
SSRIs compared to NaSSAs for adults with panic disorder
Population: adults with panic disorder
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
failure to respond SSRIs vs NaSSAs | no estimate extracted | 0 studies · 0 participants | Ungraded |
total number of dropouts SSRIs vs NaSSAs | RR 1.5 [0.29, 7.73] | 1 study · 30 participants | Low Downgraded: imprecision |
failure to remit SSRIs vs NaSSAs | no estimate extracted | 0 studies · 0 participants | Ungraded |
panic symptoms SSRIs vs NaSSAs | no estimate extracted | 1 study · 22 participants | Low Downgraded: imprecision |
number of dropouts due to adverse events SSRIs vs NaSSAs | RR 1.5 [0.29, 7.73] | 1 study · 30 participants | Low Downgraded: imprecision |