Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

584 questions · 590 findings · 240 reviews

No studies found 106 · 18%GRADE not reported 94 · 15.9%Very low 137 · 23.2%Low 134 · 22.7%Moderate 98 · 16.6%High 21 · 3.6%

Mixed action antidepressant vs placebo

Participants with at least some Side Effects · cannabis dependence

Mixed action antidepressant showed no clear difference in participants experiencing adverse effects compared with placebo (low certainty).

1 finding from 1 review

Buspirone vs placebo

Participants with at least some Side Effects · cannabis dependence

Buspirone showed no clear difference in participants experiencing adverse effects compared with placebo (low certainty).

1 finding from 1 review

N‐acetylcysteine vs placebo

Participants with at least some Side Effects · cannabis dependence

N‐acetylcysteine showed no clear difference in participants experiencing adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Dietary supplements (Catuama herbal compound) vs placebo

Adverse effects: exacerbation of symptoms · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (Catuama herbal compound) changes adverse effects: exacerbation of symptoms compared with placebo (very low certainty).

1 finding from 1 review

Paracetamol (single administration, any dose) vs placebo

Maternal drug adverse effects (sleepiness) · women with perineal pain following childbirth

Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (sleepiness) compared with placebo (low certainty).

1 finding from 1 review

Laxative vs placebo

Adverse effects on women: abdominal cramps · women in the postpartum period

Laxative may leads to higher adverse effects on women: abdominal cramps compared with placebo (low certainty).

1 finding from 1 review

Antibiotic prophylaxis vs no treatment or placebo

Adverse effects of antibiotics (skin rash) · Women who had normal vaginal births

It is very uncertain whether routine antibiotic prophylaxis changes adverse effects of antibiotics (skin rash) compared with no treatment or placebo (very low certainty).

1 finding from 1 review

Perampanel add‐on vs placebo

Withdrawals due to adverse events · people (aged 12 years and over) with drug‐resistant focal epilepsy

Perampanel add‐on may leads to higher treatment withdrawal due to adverse effects compared with placebo (low certainty).

1 finding from 1 review