Cochrane · systematic review · CD008407
Paracetamol/acetaminophen (single administration) for perineal pain in the early postpartum period
Abalos, E, Sguassero, Y, Gyte, GML · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
4
No studies
1
Included studies
NR
No studies 1 · 20%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Paracetamol (single administration, any dose) compared to placebo for perineal pain in the early postpartum period
Population: women with perineal pain following childbirth
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Adequate pain relief as reported by women Paracetamol (single administration, any dose) vs placebo | RR 2.14 [1.59, 2.89] | 10 studies · 1279 participants | Low Downgraded: risk of bias, inconsistency |
Additional pain relief Paracetamol (single administration, any dose) vs placebo | RR 0.34 [0.21, 0.55] | 8 studies · 1132 participants | Low Downgraded: risk of bias, inconsistency |
Maternal drug adverse effects (nausea) Paracetamol (single administration, any dose) vs placebo | RR 0.18 [0.01, 3.66] | 1 study · 232 participants | Low Downgraded: imprecision |
Maternal drug adverse effects (sleepiness) Paracetamol (single administration, any dose) vs placebo | RR 0.89 [0.18, 4.3] | 1 study · 232 participants | Low Downgraded: imprecision |
Neonatal drug adverse effects Paracetamol (single administration, any dose) vs placebo | no estimate extracted | NR | No studies |