Cochrane · systematic review · CD005944

Vitamin A supplementation for postpartum women

Oliveira, JM, Allert, R, East, CE · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

Pregnancy and Childbirth2 versionsAMSTAR 2: not assessed

SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.

Questions

current version

GRADE rated

No studies

Included studies

No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

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Vitamin A supplementation (200,000 to 400,000 IU) compared to placebo or no treatment in postpartum women

Population: Postpartum women

7 questions

Outcome	Effect	Evidence	Status / GRADE
Maternal mortality Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	HR 1.01 [0.44, 2.21]	1 study · 8577 participants	Moderate Downgraded: imprecision
Maternal morbidity (diarrhoea, respiratory infections, fever) Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	no estimate extracted	1 study · 50 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Maternal adverse effects after administration: abdominal pain Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	RR 1.28 [0.95, 1.73]	1 study · 786 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Maternal breast milk retinol concentration Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	no estimate extracted	6 studies · 837 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Infant mortality Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	RR 1.08 [0.77, 1.52]	5 studies · 6090 participants	Low Downgraded: risk of bias, imprecision, inconsistency
Infant morbidity (gastroenteritis) Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	RR 6.03 [0.3, 121.82]	1 study · 84 participants	Very low Downgraded: risk of bias, imprecision, inconsistency
Infant adverse effects: bulging fontanelle Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment	RR 2 [0.61, 6.55]	1 study · 444 participants	Low Downgraded: risk of bias, imprecision, inconsistency