Cochrane · systematic review · CD005944
Vitamin A supplementation for postpartum women
Oliveira, JM, Allert, R, East, CE · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Current version onlyVitamin A supplementation (200,000 to 400,000 IU) compared to placebo or no treatment in postpartum women
Population: Postpartum women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | HR 1.01 [0.44, 2.21] | 1 study · 8577 participants | Moderate Downgraded: imprecision |
Maternal morbidity (diarrhoea, respiratory infections, fever) Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Maternal adverse effects after administration: abdominal pain Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | RR 1.28 [0.95, 1.73] | 1 study · 786 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Maternal breast milk retinol concentration Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | no estimate extracted | 6 studies · 837 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Infant mortality Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | RR 1.08 [0.77, 1.52] | 5 studies · 6090 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Infant morbidity (gastroenteritis) Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | RR 6.03 [0.3, 121.82] | 1 study · 84 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Infant adverse effects: bulging fontanelle Vitamin A supplementation (200,000 to 400,000 IU) vs placebo or no treatment | RR 2 [0.61, 6.55] | 1 study · 444 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Vitamin A supplementation compared to placebo for postpartum mothers
Population: postpartum mothers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Maternal mortality Vitamin A supplementation vs placebo | HR 1.11 [0.81, 1.51] | 1 study · 8577 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Maternal morbidity: Infections (total days of illness per days of Vitamin A supplementation vs placebo | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Maternal adverse effects after administration: vomiting Vitamin A supplementation vs placebo | RR 0.33 [0.03, 3.14] | 1 study · 786 participants | Low Downgraded: imprecision, inconsistency |
Maternal serum retinol (mcmol/L) mcmol/L Vitamin A supplementation vs placebo | no estimate extracted | 3 studies · 258 participants | Low Downgraded: risk of bias |
Maternal low hepatic vitamin A stores (MRDR greater than or equal to 0.06) Vitamin A supplementation vs placebo | RR 0.33 [0.15, 0.71] | 1 study · 69 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Maternal low hepatic vitamin A stores (RDR > 20%) Vitamin A supplementation vs placebo | RR 1.15 [0.41, 3.25] | 1 study · 139 participants | Moderate Downgraded: risk of bias, imprecision, inconsistency |