Surgical field bleeding score (during surgery or < 30 minutes after surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps
1 finding from 1 review
Intraoperative blood loss (mL) · adults and children with chronic rhinosinusitis with or without nasal polyps
1 finding from 1 review
Significant adverse events (seizures, thromboembolism) within 24 hours of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps
Tranexamic acid showed no clear difference in significant adverse events (seizures, thromboembolism) within 24… compared with placebo (saline solution or sterile water) (moderate certainty).
1 finding from 1 review
Duration of surgery (minutes) Assessed as: total surgical time · adults and children with chronic rhinosinusitis with or without nasal polyps
1 finding from 1 review
Incomplete surgery · adults and children with chronic rhinosinusitis with or without nasal polyps
Tranexamic acid showed no clear difference in incomplete surgery compared with placebo (saline solution or sterile water) (moderate certainty).
1 finding from 1 review
Overall rate of surgical complications · adults and children with chronic rhinosinusitis with or without nasal polyps
Tranexamic acid showed no clear difference in surgical complications compared with placebo (saline solution or sterile water) (moderate certainty).
1 finding from 1 review
Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps
Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).
1 finding from 1 review
Control of epistaxis: episodes of re‐bleeding over 10 days All treatments (topical and oral) · adults with nasal haemorrhage (epistaxis)
Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days All… compared with placebo plus usual care or usual care alone (moderate certainty).
1 finding from 1 review
Severity of re‐bleeding: proportion of patients requiring blood transfusion within 10 days · adults with nasal haemorrhage (epistaxis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Length of hospital stay · adults with nasal haemorrhage (epistaxis)
1 finding from 1 review
no estimate extracted
10 participants
GRADE not reported
Adverse effects: serious or other · adults with nasal haemorrhage (epistaxis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Control of epistaxis: episodes of re‐bleeding over 10 days Oral treatment only · adults with nasal haemorrhage (epistaxis)
Tranexamic acid probably leads to lower control of epistaxis: episodes of re‐bleeding over 10 days Oral… compared with placebo plus usual care or usual care alone (moderate certainty).
1 finding from 1 review
Control of epistaxis: episodes of re‐bleeding over 10 days Topical application (10% gel) only · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in control of epistaxis: episodes of re‐bleeding over 10 days Topical… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
Control of epistaxis: time to stop initial bleeding (proportion of patients whose bleeding is controlled in ≤ 30 minutes) · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in control of epistaxis: time to stop initial bleeding (proportion of… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
Severity of re‐bleeding: proportion of patients requiring blood transfusion within 10 days · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in severity of re‐bleeding: proportion of patients requiring blood… compared with placebo plus usual care or usual care alone (low certainty).
1 finding from 1 review
Length of hospital stay · adults with nasal haemorrhage (epistaxis)
Tranexamic acid showed no clear difference in length of hospital stay compared with placebo plus usual care or usual care alone; GRADE not reported.
1 finding from 1 review
Adverse effects: serious or other · adults with nasal haemorrhage (epistaxis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Control of epistaxis: episodes of re‐bleeding over 10 days · adults with nasal haemorrhage (epistaxis)
1 finding from 1 review
no estimate extracted
10 participants
GRADE not reported
Control of epistaxis: time to stop initial bleeding (proportion with bleeding controlled within 10 minutes) · adults with nasal haemorrhage (epistaxis)
Tranexamic acid probably leads to higher control of epistaxis: time to stop initial bleeding (proportion with… compared with other haemostatic agent (moderate certainty).
1 finding from 1 review
Blood loss > 400 mL or > 500 mL · pregnant women undergoing vaginal or caesarean birth who received TA for the prevention of postpartum haemorrhage
Tranexamic acid probably leads to lower blood loss > 400 mL or > 500 mL compared with placebo/no treatment (moderate certainty).
1 finding from 1 review