Patients not using rescue medication at 8 hours · Patients with pain after surgical removal of lower wisdom teeth (third molars) requiring bone removal or with baseline moderate to severe…
Combined paracetamol plus ibuprofen in a single tablet (e.g.… leads to higher patients not using rescue medication at 8 hours compared with single drugs given separately (paracetamol 1000 mg or ibuprofen 400… (high certainty).
1 finding from 1 review
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA
Paracetamol plus ibuprofen (oral or IV) showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA
Paracetamol plus ibuprofen (oral or IV) showed no clear difference in necrotizing enterocolitis during initial hospital stay (radiological… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).
1 finding from 1 review
Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA
Prophylactic administration of paracetamol may leads to lower failure of PDA closure after first course (assessed by… compared with placebo or no intervention (low certainty).
1 finding from 1 review
All‐cause mortality during hospital stay · preterm infants with PDA
Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).
1 finding from 1 review
Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm infants with PDA
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adequate pain relief as reported by women · women with perineal pain following childbirth
Paracetamol (single administration, any dose) may leads to higher adequate pain relief as reported by women compared with placebo (low certainty).
1 finding from 1 review
Additional pain relief · women with perineal pain following childbirth
Paracetamol (single administration, any dose) may leads to lower additional pain relief compared with placebo (low certainty).
1 finding from 1 review
Nausea · women with perineal pain following childbirth
Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (nausea) compared with placebo (low certainty).
1 finding from 1 review
Maternal drug adverse effects (sleepiness) · women with perineal pain following childbirth
Paracetamol (single administration, any dose) showed no clear difference in maternal drug adverse effects (sleepiness) compared with placebo (low certainty).
1 finding from 1 review
Neonatal drug adverse effects · women with perineal pain following childbirth
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Moderate benefit: At least 30% reduction in pain, or PGIC much or very much improved · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Substantial benefit: At least 50% reduction in pain, or PGIC much improved · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Lack of efficacy withdrawal · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Withdrawals due to adverse events · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Serious adverse events · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Deaths · adults with chronic neuropathic pain
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
At least 50% reduction in pain · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported.
3 findings from 1 review
RR 4.87 [2.83, 8.37]
17 studies · 1658 participants
GRADE not reported
RR 3.41 [2.34, 4.97]
13 studies · 1184 participants
GRADE not reported
RR 2.85 [1.89, 4.29]
16 studies · 1498 participants
GRADE not reported
Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.
1 finding from 1 review