Question · asked by 1 review
Oral paracetamol vs placebo: At least 50% reduction in pain
- Population
- Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local anaesthesia, intravenous sedation, or general anaesthesia; patients taking concurrent analgesia excluded)
- Intervention
- Oral paracetamol
- Comparison
- placebo
- Outcome
- At least 50% reduction in pain
Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported.
What each review found
Include earlier review versionsNo studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Paracetamol (single oral dose, any dose or formulation; subgroups up to 1000 mg and 1000 mg or more) vs Placebo Achieving at least 50% pain relief at 4 hours (using pain intensity measurements / SPID) · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery… · 4 hours Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain intensity… compared with placebo; GRADE not reported. Paracetamol for pain relief after surgical removal of lower wisdom teeth (2007) · Cochrane All outcomes | RR 4.87 [2.83, 8.37] | 17 studies · 1658 participants | GRADE not reported |
Paracetamol (single oral dose, any dose or formulation; subgroups up to 1000 mg and 1000 mg or more) vs Placebo Achieving at least 50% pain relief at 6 hours (using pain intensity measurements / SPID) · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery… · 6 hours Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 6 hours (using pain intensity… compared with placebo; GRADE not reported. Paracetamol for pain relief after surgical removal of lower wisdom teeth (2007) · Cochrane All outcomes | RR 3.41 [2.34, 4.97] | 13 studies · 1184 participants | GRADE not reported |
Paracetamol (single oral dose, any dose or formulation; subgroups up to 1000 mg and 1000 mg or more) vs Placebo Achieving at least 50% pain relief at 4 hours (using pain relief measurements / TOTPAR) · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery… · 4 hours Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 4 hours (using pain relief… compared with placebo; GRADE not reported. Paracetamol for pain relief after surgical removal of lower wisdom teeth (2007) · Cochrane All outcomes | RR 2.85 [1.89, 4.29] | 16 studies · 1498 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Paracetamol for pain relief after surgical removal of lower wisdom teeth 2007 · Cochrane All outcomes | 2006-08 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.