Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,024 questions · 3,338 findings · 330 reviews

No studies found 735 · 22%GRADE not reported 282 · 8.4%Very low 962 · 28.8%Low 870 · 26.1%Moderate 384 · 11.5%High 105 · 3.1%

Topical interventions (sucralfate, interferon-alpha, cyclosporin A) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • SoF (topical interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim): "5 placebo-controlled trials evaluated topical interventions (sucralfate suspension (2 trials), interferon-alpha (2…
    Studies not reported
    GRADE not reported

Multi‐component intervention vs other treatments/routine care

Number experiencing adverse effects · the management of chronic obstructive pulmonary disease

It is very uncertain whether multi‐component intervention changes adverse events: number of people experiencing an AE compared with other intervention or routine, usual care or control treatment (very low certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Number of participants experiencing any serious adverse events · the management of chronic obstructive pulmonary disease

Multi‐component intervention showed no clear difference in adverse events: number of people experiencing a serious adverse event compared with other intervention or routine, usual care or control treatment (low certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · the management of chronic obstructive pulmonary disease

It is very uncertain whether multi‐component intervention changes exacerbations: number of people experiencing at least one exacerbation compared with other intervention or routine, usual care or control treatment (very low certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Quality of care: healthcare professional adherence to EBP at 12 months · healthcare professionals providing stroke rehabilitation

It is very uncertain whether implementation interventions changes quality of care: healthcare professional adherence to EBP at 12 months compared with no intervention (very low certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Patient adherence to recommended treatment: number of outdoor journeys per week at 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient adherence to recommended treatment: number of outdoor… compared with no intervention (low certainty).

1 finding from 1 review

Implementation interventions vs no intervention

HRQoL at 6 or 12 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: HRQoL (EQ‐5D: –0.59 to 1, higher score… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Patient health status: ADL (Barthel Index, 0–20, higher score = better) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: ADL (Barthel Index, 0–20, higher score =… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions vs no intervention

Patient health status: psychological well‐being (GHQ‐12, 0–36, higher score = worse) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: psychological well‐being (GHQ‐12, 0–36,… compared with no intervention (low certainty).

1 finding from 1 review